RB LEIPZIG came out 3-1 victors over Celtic, who remain without a win in this season's Champions League.
Christopher Nkunku saw an early strike disallowed before rounding Joe Hart later in the first-half to see his side go in one goal up.
Jota equalised in the second period, getting onto a pull-back to convert before Dominik Szoboszlai thought he put Leipzig back ahead, just for the goal to be disallowed as an offside player affected Hart's view.
Andre Silva netted his first of the match just moments later to put his side ahead, capitalising on a mistake from the Celtic goalkeeper before adding his second as the Germans came out 3-1 victors.
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Hoops struggle on the road
Celtic have now failed to win in Germany in 14 attempts.
It is now five years since The Hoops won an away game in the UEFA Champions League.
Without picking up points away from home, you make any passage out of the group phase near impossible.
FT: RB Leipzig 3-1 Celtic
The referee brings the game to a close.
It is a long trip back from Germany for the Celtic fans after a disappointing defeat.
The reverse fixture at Celtic Park is now a 'must win' game for Ange Postecoglou's side.
RB Leipzig 3-1 Celtic
90+4. Since the introduction of VAR it seems we are never going to get a football match that does not have at least five minutes added on.
The ball comes to Forsberg on the edge of the box, he takes one touch and shoots at goal.
His shot goes a few feet wide of the far post.
RB Leipzig 3-1 Celtic
90+2. Jota is fouled on the halfway line.
Jovanovic looks to play it forward but gifts it to Forsberg.
Leipzig are still looking for more goals here.
RB Leipzig 3-1 Celtic
90. We are going to have an additional five minutes added here.
Still not enough time for Celtic to turn this game around you feel.
Never say never, stranger things have happened in football.
RB Leipzig 3-1 Celtic
88. Celtic would have thought all their prayers had been answered with Leipzig having their goal disallowed, very harshly.
No sooner had VAR saved the Scottish side, Joe Hart's misplaced pass restores balance in the universe from a German perspective.
There does not seem enough time left for Celtic to find a way back into this game now.
RB Leipzig 3-1 Celtic
86. You cannot deny Leipzig their win this evening.
Scoring five goals but only three of them counting.
It also makes the reverse fixture next week at Celtic Park is of huge importance now to Ange Postecoglou's side.
RB Leipzig 3-1 Celtic
84. McCarthy gets involved straight away.
He feeds Taylor who looks to cross from the edge of the box with a lot of pace on the ball.
It takes a deflection and goes over the crossbar for a corner.
RB Leipzig 3-1 Celtic
82. Some more changes for the home side.
Halstenberg comes on for Raum.
Poulsen comes on for Szoboszlai who gets a standing ovation.
Giakoumakis comes on for Kyogo.
McCarthy comes on for Hatate.
RB Leipzig 3-1 Celtic
80. Celtic need to be wary now.
If they let their performance slip in these final ten minutes or so Leipzig could turn this scoreline into a rout.
With the potential of the head to head record between the sides coming into play in the group standings, the final result this evening could be key.
RB Leipzig 3-1 Celtic
78. Nkunku plays a lofted ball out wide to Simakan.
His cushioned volley is straight into the path of Andre Silva.
With Hart sprawling across his goal, he slots the ball home.
Goal - Andre Silva (RB Leipzig)
RB Leipzig 2-1 Celtic
76. Time is not on Celtic's side right now.
Leipzig know that one more goal would put this game to bed.
Forsberg is already causing issues for the Celtic backline.
RB Leipzig 2-1 Celtic
74. The problem for Celtic now is the more they push forward in search of an equaliser, they leave themselves open to the counter-attack.
Szoboszlai goes to ground on the edge of the box looking for a free kick but the referee is not having any of it.
The Hungarian winger is receiving some treatment.
Forrest comes on for Maeda.
Haksabanovic comes on for O'Riley.
RB Leipzig 2-1 Celtic
72. You can really see why so many teams are interested in Christopher Nkunku.
He really looks a special player.
Leipzig continue to come forward but a loose pass gifts it to Jota.
RB Leipzig 2-1 Celtic
70. Ange Postecoglou needs to get his team going in these final twenty minutes in Germany.
Since the goal, heads seem to have dropped.
Leipzig on the other hand have scored 4 goals tonight and find themselves 2-1 up.
Werner comes off for Forsberg.
Kampl comes off for Haidara.
RB Leipzig 2-1 Celtic
68. What a period of play that was.
Goals disallowed harshly and then Celtic gift the hosts a goal.
What was Joe Hart thinking of, only he will know.
Terrible error.
RB Leipzig 2-1 Celtic
66. Joe Hart will not want to see this one again.
In no danger whatsoever, he passes the ball to Szoboszlai.
He slides Andre Gomes in who slots the ball passed the embarrassed Joe Hart.
Goal - Andre Silva (RB Leipzig)
RB Leipzig 1-1 Celtic
64. Unbelievable scenes!
Celtic fans celebrate the decision like they have scored themselves.
Incredibly harsh on the Germans.
RB Leipzig 2-1 Celtic
62. VAR is checking this one.
Szoboszlai cuts inside from the left onto his favoured right foot.
He strikes the ball from distance into the bottom corner.
Andre Gomes ducked underneath the shot but he may have been in Joe Hart's eyeline.
The referee is heading over to the monitor.
Goal - Szoboszlai (RB Leipzig)
RB Leipzig 1-1 Celtic
60. O'Riley receives a yellow card.
Trying to hold the ball up he catches his marker with a stray arm.
The Celtic fans are all that can be heard at the moment.
RB Leipzig 1-1 Celtic - Szoboszlai chance!
58. Great one touch football by Leipzig.
A chance opens up for Szoboszlai whose shot beats Hart but is denied by the woodwork.
The ball clips off the post and clear.
RB Leipzig 1-1 Celtic
56. Hatate is getting more involved in the game and causing problems down the right wing.
On this occasion the ball is slightly overrun and he cannot keep it in play.
Leipzig immediately look to attack themselves.
The cross finds Andre Silva but his header is tame and easily collected by Joe Hart.