The protest, organised by Youth Strike for Climate Change Liverpool, was part of a coalition of students across the UK and worldwide.
The march, which began at 12pm at St George’s Hall and concluded with speeches at Derby Square, followed a similar format to the walk out last month, when thousands of students across UK towns and cities protested against government inaction on climate change.
Event organiser, Abhijith Subramanian, 18, said: “ There is a shocking lack of regard for the climate by our politicians - that is what got me involved within the movement.
“I wanted to say - 'hey listen - it’s our future and it’s our planet to inherit. Why are you selling away our futures, why are you selling centuries to buy yourselves five years in office?'
“We are encouraging people to talk to their friends, to raise awareness and talk to their MPs and local politicians in order to pressure to them to act.”
The children were joined by supportive parents, grandparents and university students.
Protester Pablo Guidi, 45, said: “My children (11, 9 and 5) brought me out today. They heard about it through the actions of other young people who have been protesting.
"There is no point going to school if there is no planet."
PHD student, Hannah Branwood, 23, said: “The IPCC (The UN Intergovernmental Panel on Climate Change) has said that we have 12 years to make changes and the government is just not doing enough".
Fellow student, 25-year-old Karen Wase, said “This has been surprisingly very powerful - just us walking down the street. It is really nice to see the younger generation so passionate about it.
"There are a lot of older people here supporting us as well - they understand that they are leaving a planet behind for the younger generation and they want to do better for their kids.”
Luke Myer, education officer at Edge Hill University Student Union, tweeted that there were "900 young people calling for action on climate change". He added: "These kids are the future."
On the Facebook event, Youth Climate Strike Liverpool, 214 people recorded themselves as going.
The movement was inspired by Swedish climate activist Greta Thunberg, who in 2018, skipped Friday classes to sit outside government buildings, in a bid to raise awareness of global warming.
Thousands of environmentally conscious students across the globe, working within activist groups such as Youth Strike 4 Climate, the UK Student Climate Network and Schools 4 Climate Action, are expected to walk out of school on Friday to march.