Conservative MPs based in Northern England have called on the Prime Minister to provide a clear roadmap out of local lockdowns.
Over 50 MPs have signed a letter, seen by the Guardian, from the Northern Research Group, which is led by former northern powerhouse minister Jake Berry.
The 55 MPs express concerns that the critical levelling-up agenda could be sacrificed by the cost of Covid-19, and that northern constituencies would be left behind.
Forty-one are named, many from former "red wall" seats, plus two from north Wales and one from Scotland, while 14 are anonymous, the Guardian reports.
More regions will now join the likes of Greater Manchester in Tier 3 regulations, following further announcements on Monday afternoon.
Of these areas, 92 per cent are in the North of England.
Greater Manchester is still reeling after a week of tense talks over how much financial support would be offered to the region, as it came under the strictest lockdown measures.
The MPs said: "We believe this would threaten to undermine the government’s hard-won mandate in December, at a time when the political and economic case for the levelling-up agenda we have been elected to deliver has never been more essential."
MPs said that the North had seen a level of disruption "unparallelled with other parts of the country," as they called for greater clarity about the way out of local lockdowns.
"Northern parts of our country were among the first to be significantly adversely affected by the Covid outbreak, and now many communities have been put back under severe restrictions," the letter said.
MPs encouraged Boris Johnson to create a pathway down the tiering system, and called for a Northern Economic Recovery Plan.
The Prime Minister should develop "a tailored economic recovery plan" for the north, they say.
William Wragg, MP for Hazel Grove in Stockport told the Guardian: “We have long needed a good deal for the north from the government, and the virus has only exacerbated that need.
"This isn’t about giving government a tough time. The prime minister shares our collective priority.
"But there are compelling and constructive arguments we, as a group of northern MPs, can make to government about how it delivers on its promise to level up the north."
A No 10 spokesman said: "We are absolutely committed to levelling up across the country and building back better after coronavirus.
"We stood at the last election on a solemn promise that we would improve people’s lives, and although the pandemic has meant 2020 is not the year we all hoped it would be, our ambitions for the country are unchanged."