A crash 'resulting from an emergency services incident' has shut Rush Green Road in Romford in both directions.
The road has been closed at the junction with Dagenham Road.
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TfL said the collision had resulted from an emergency services incident.
"Traffic is slow on local diversion - expect delays in the area," TfL said.
Witnesses said the crash happened around 5.30pm. Emergency services are on scene.
More to follow.