When you feel pain, it's natural to do everything you can to relieve it immediately. However, according to experts, takingpainkillersin a hurry may not be the best way to relieve pain. It has been found that it can affect the rate at which the stomach absorbs orally ingested drugs.
So when you expect much-needed pain relief, you will want to adjust your position. Studies show that lying on your right side is more effective when taking medication. But don't turn your back, according to findings published in the journal Physics of Fluids.
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An artistic biomimetic simulator called "StomachSim" was used for research.
According to them, this modeling was the first to combine gastric biomechanics with tablet movement and drug dissolution to quantify the active pharmaceutical ingredient entering the duodenum through the pylorus.
This allows researchers to calculate and compare the excretion rate and release of dissolved active pharmaceutical ingredients into the duodenum for different physiological conditions. I was.
His professor at Johns Hopkins University, Rajat Mittal, co-author of the study, said: , the movement of the stomach wall and the flow of the internal contents determine the rate at which it dissolves.The properties of the tablet and the stomach contents also play a large role.
"However, current experimental or clinical procedures for assessing oral drug dissolution are limited in our ability to study this, and are often used in a variety of gastric disorders such as gastroparesis. It is difficult to understand how dissolution is affected in the drug. One of the factors involved in bioavailability, he said, is that stomach contractions can cause pressure and create complex tablet trajectories.
Professor Mittal said: } "Together, these issues pose several challenges to the design of drug delivery."
Professor Mittal added: "In this study, we demonstrate a new computer simulation platform that offers the potential to overcome these limitations.
"Our model addresses the complex physiological processes behind oral administration of tablets. We can generate biologically relevant data on drug dissolution that can provide useful and unique insights to the world.”
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