Dr. Chris Pernell, a New Jersey physician who lost her father to Covid-19, told CNN on Thursday that she was on the phone with friends the previous night, asking them to reverse their travel plans.
"I pleaded with them: Please, stay home. Be safe so you can enjoy your loved ones in the future," Pernell said.
The average number of daily deaths across a week -- 1,658 on Wednesday -- is the highest it's been since mid-May.
Expert: Daily deaths could double soon
One expert predicts daily Covid-19 deaths will double in just a matter of days.
"When you look at people who are hospitalized today, they were infected two weeks ago, maybe more. So, it takes about five to seven days to become symptomatic," Dr. Jonathan Reiner, a professor of medicine at George Washington University, said Wednesday.
"Usually, it takes about another week to be sick enough to be hospitalized so that's two weeks at least, and then it takes usually another week for folks to succumb to the illness," Reiner said.
"I expect that the daily death rate will double in the next 10 days," he said. "We'll be seeing close to 4,000 deaths a day."
'We will see a surge upon a surge'
With the country deep into the fall Covid-19 surge, local and state leaders made last-ditch attempts all week to get the warning out to Americans: don't opt for traditional Thanksgiving celebrations this year, or things could get worse.
Phone alerts were sent out in Pennsylvania and parts of Georgia urging residents to stay safe during the holiday. In New Orleans officials sent residents a reminder to celebrate within their own household and keep larger celebrations virtual. In a final plea to Kansans, Gov. Laura Kelly said following health regulations "will be more critical than ever in the coming days." US Surgeon General Dr. Jerome Adams said the safest Thanksgiving this year includes only immediate household members.
Similar warnings have poured in during the past week from officials in almost every state. And experts have cautioned of what could happen in the coming weeks if Americans don't heed the guidance.
"It is kind of serious news here with all those people traveling and then at their destinations spending a lot of time indoors in a warm family relationship with extended families," Dr. William Schaffner, professor of infectious diseases at Vanderbilt University, said Wednesday night.
"The virus is going to attend some of those Thanksgiving dinners and will spread, I'm afraid. And then people will come home, some of them will become ill, spread it further into their families and into their neighborhoods," he added.
"In a week, more likely two weeks, we will see a surge upon a surge," Schaffner said. "We're in for a tough time."
CDC study: It's possible that only 1 in 8 US infections have been counted
Only about 1 in 8 -- or 13% -- of all coronavirus infections in the United States were recognized and reported through the end of September, a new modeling study suggests.
That estimate, made by researchers at the US Centers for Disease Control and Prevention, would mean that as many as 53 million people in the United States could have been infected from February through September.
During that same period, around 7 million confirmed cases of symptomatic Covid-19 were reported nationally, the researchers said.
To estimate the number of Covid-19 cases that might have been missed since the beginning of the pandemic, the researchers used a model to adjust the reported numbers of symptomatic cases in the United States. They considered what's known about detecting cases, asymptomatic cases, patients seeking care or not and the risk of false negative test results.
Their study had some limitations, including that the availability and use of testing has changed over time, and their findings are based on a probabilistic model -- so they serve only as estimates.
Overall, while the numbers of Covid-19 cases in the study may seem large, the researchers emphasized that 84% of the US population would not have been infected by the end of September, and that therefore "most of the country remains at risk, despite already high rates of hospitalization."