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Why I'm Tired from Desk Work All Day

A long, hard day of thinking can be as exhausting as a day of manual labor. Scientists say they have figured out why.

Researchers believe their findings suggest thatthe reason people are mentally exhausted by intense thinkingand do not feel sleepyis not just in their heads. indicates that the

According to this study,hours of intense mental workaccumulate a potentially toxic by-product in a part of the brain known as the prefrontal cortex.

This alters human control over decision-making and, when mental fatigue sets in, moves to action that does not require effort or waiting.

This fatigue tells the brain to shut down. to save yourself.

Matthias Pesiglione of Pitie-Salpetriere University in France said:

"However, our findings show that cognitive tasks lead to true functional changes, the accumulation of toxic substances, so fatigue is indeed a signal to stop us doing our jobs." But it serves another purpose: maintaining brain integrity.

The researchers looked at two groups of people and monitored their brain chemistry throughout the day.

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The group doing hard work showed signs of fatigue, such as decreased pupillary dilation.

I chose the option that suggested a reward.

Importantly, the researchers also noted that the prefrontal cortex of the brain had higher levels of a chemical called glutamate.{27

Together with previous evidence, the authors say they support the idea that glutamate accumulation is costly for further activation of this part of the brain.

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