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One win could mean a spot in the last 16 for both Uruguay and Ghana on Friday - though only the latter have that guaranteed.
It’s possible the South Americans win and still go out, if South Korea also beat already-qualified Portugal and maintain a better goal difference than Darwin Nunez and co.
Ghana have been very impressive in spells at the World Cup, considering they are effectively a new team with plenty of inexperienced players at international level.
The likes of Mohammed Kudus and Jordan Ayew have been very influential, while Inaki Williams has led the line well despite still waiting for his first goal for the national team.
Here’s everything you need to know ahead of the game.
When is the match?
Ghana face Uruguay at 3pm GMT on Friday 2 December.
Where can I watch it?
The match will be broadcast live on BBC Two and can be streamed on the BBC iPlayer.
The Independent will be covering this game and all others at the World Cup with our live blog commentary.
What is the team news?
There is a full squad available for Ghana, so the most likely scenario is an unchanged line-up from their last game. Pushing Mohammed Kudus further upfield was an important tactical switch for that game and he will again be key in supporting striker Inaki Williams.
Uruguay have played both a back three and back four so far but look better-balanced in the 3-5-2. Edinson Cavani may get the nod in attack over Luis Suarez again, especially given the furore around the former Liverpool and Barcelona man in this specific fixture. Centre-back Ronald Araujo is still out injured.
Predicted lineups
GHA - Zigi, Lamptey, Amartey, Salisu, Mensah, Partey, Samed, Kudus, A Ayew, J Ayew, Williams
URU - Rochet, Gimenez, Godin, Coates, Varela, Valverde, Bentancur, Vecino, Oliveira, Cavani, Nunez
Odds
Ghana 4/1
Draw 29/10
Uruguay 4/5
Prediction
No repeat of the acrimonious meeting last time and no fairytale comeback for the South Americans, who have been well below par. They might not lose but it won’t be enough. Ghana 2-2 Uruguay.
