On Tuesday, US health officials expanded the limited supply of themonkeypoxvaccine by giving people one-fifth the normal dose. approved the plan to is as effective as
The so-called dose-sparing approach also calls for the Jynneos vaccine to be injected just under the skin rather than in deeper tissues. The recipient will get his two shots at four week intervals.
The highly unusual measure underlines that the United States currently lacks the supplies needed to vaccinate everyone seeking protection from the rapidly spreading virus. I acknowledged it.
Read more: The United States has declared monkeypox a health emergency. Canada should follow suit.
This includes 1.7 million Americans to the 1.6 million whom federal officials consider to be at highest risk for the disease, primarily for his HIV Men who are infected or at high risk of infection. To vaccinate that group would require a full dose of about three times the 1.1 million people the authorities have made available.
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The White House monkeypox response coordinator, Robert Fenton, said the plan would help the US "get ahead of the virus."
"This is safe and effective and will significantly expand the dose of vaccine available to communities across the country," Fenton told reporters.
Last week, it declared monkeypox a public health emergency. to slow the spread of an outbreak that has infected more than 8,900 Americans. Officials announced another decision on Tuesday. This will allow the Food and Drug Administration to expedite the review of medical products or their new uses, such as the dose-saving technology of Gynneos.
Approved a new approach for older adults. Young people can be vaccinated if they are judged to be at high risk, but they must have a conventional injection.
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The announcement was made last month by the FDA and other agencies that he needed two doses of vaccine in sufficient doses. This is a complete turnaround from repeatedly emphasizing that there is. protection.
However, regulators are now reporting that a 2015 study found that one-fifth the conventional dose of the vaccine produced an immune system response as strong as the full dose. pointing out. A study funded by the National Institutes of Health found that about 94% of people given low doses had sufficient levels of antibodies to fight the virus, whereas those given full doses
Read more: Monkeypox: US declares health emergency amid epidemic
The NIH will release the technology in the coming months, according to the agency.
Because vaccine manufacturers often prescribe shots to provide more than adequate protection, it is not uncommon for lower doses to prove effective.
} However, some experts and advocates warn that there is little data to support the policy, and fear it could backfire if the vaccine becomes less effective.61}
I fear that it is a stray and gives people a false sense of confidence that they are protected," David Harvey of the National Coalition of STD Directors said in a statement.
A smaller dose would also require a different type of injection that penetrates only the upper layers of the skin, rather than the lower layers between the skin and muscle. This is a less common technique and may require training of some healthcare workers. It also has side effects such as redness, itching, and swelling.
Shallow injections are thought to help stimulate the immune system because the skin contains numerous immune cells that target foreign invaders.
The Centers for Disease Control and Prevention said it would provide educational materials on the technology as well as conduct a broader awareness campaign for the US health sector.
Vaccine dose rationing is common in Africa and other parts of the world where medical resources are limited. In recent years, the World Health Organization has endorsed approaches to combat yellow fever, polio, and other disease outbreaks.
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"This is not an uncommon situation," said Dr. William Moss of Johns Hopkins University Vaccine Access Center. increase. "It comes down to public health decision-making. Do you make this trade-off during an outbreak of inadequate supply?"
Read more: Monkeypox: Biden promises to accelerate virus response as more states declare emergency
First COVID- 2020 With 19 vaccines available later in the year, the UK government made it a priority to give as many people as possible the first dose before giving them the second.
Both the United Kingdom and Canada have adopted single-dose vaccine strategies that prioritize those at highest risk of monkeypox. And the health departments of several large US cities, including New York, San Francisco and Washington, have adopted similar strategies amidst limited supplies.
We have shipped more than 617,000 doses of the vaccine to health authorities in the world, and we plan to distribute another 380,000 doses in the coming weeks. So far, it is recommended for people who have already had monkeypox or who may develop it from recent sexual contact in areas where the virus is endemic.
The Biden administration has been accused of failing to quickly sort out millions more doses from the country's strategic national stockpile. injections are not expected until 2023. : New York, the second major city to declare a state of emergency as cases spread across the United States – July 31, 2022
The US government and Danish manufacturer Bavarian Nordic has 16.1 million doses worth of bulk vaccine components under its contract. But the material must be sealed in vials, and the process is expected to take months as the small company handles orders from other countries.
HHS said last week, Responded to criticism of the pace and timing of the government's vaccine decision.
"We have carefully considered when and how we use bulk vaccines because years of shelf life are lost when they are taken out of bulk," said a spokesperson. The official said in an emailed statement.
The FDA approved his Jynneos vaccine to prevent smallpox and monkeypox in 2019, based in part on studies in monkeys. According to the FDA label, animals that received two doses of the vaccine were more than twice as likely to survive after being infected with monkeypox than animals that did not.
Read More: Monkeypox global response inadequate, AIDS experts meeting
Additional human studies have shown that people given Gineos have immune responses similar to those given previous smallpox vaccines. However, Jynneos has not been tested in humans for monkeypox or its relative smallpox, which was eradicated decades ago.
This is typical of many of the national stockpile vaccines and drugs that treat rare or deadly pathogens such as anthrax and plague.
The US government has spent over $1 billion developing and stockpiling freeze-dried vaccines, replacing earlier liquid versions with shorter shelf lives. Bavarian Nordic has a 10-year contract with the US to supply the new vaccine.
© 2022 The Canadian Press