PM faces supply crisis back home
Boris Johnson is also facing pressure back home as the government tries to grapple with rising fears about shortages of gas and supply chains.
Speaking on the tarmac at New York's JFK airport, Mr Johnson said the shortages were "a function of the world economy waking up after Covid".
He added the government would do "everything we can" to prevent energy companies from going under as gas prices surge.
Foreign Secretary joins trip
The PM will also be joined by newly appointed Foreign Secretary Liz Truss who attends her first official visit in her new role.
Speaking about the four-day visit Truss said: " I’m delighted my first international visit as Foreign Secretary is to the United States - the UK’s closest and most important partner.
"At the UN General Assembly, I look forward to convening global leaders to tackle the major issues of the day and projecting a positive, outward-looking Global Britain that delivers for people across the United Kingdom."
Foreign Secretary Liz Truss boards RAF Voyager at Stansted Airport