The 50-year-old is set to talk about his personal struggles after little Maddie vanished without a trace during a holiday in Portugal 11 years ago.
On the BBC Radio 4 special, he will speak about coping with grief and his loss in a bid to help other men open up about their emotions.
He said: “I decided it was a good opportunity to say something about the special bond between fathers and daughters, thinking that speaking openly might help other men in similar positions. It feels like the right time.”
The family were devastated after the then three-year-old vanished from their Algarve flat while they were dining with friends nearby.
“I decided it was a good opportunity to say something about the special bond between fathers and daughters”Gerry McCann
Despite searches yielding few fresh leads the McCanns still hold out hope their daughter could still be alive.
But time is running out for cops, who will have search funding cut at the end of the month – one day after the show Pear: Two Fathers, Two Daughters airs.
The programme will feature a poem translated and dramatised by Simon Ermitage and Game of Thrones star Iain Glen, respectively.
‘Pearl’, is a medieval poem that focuses on a dad who lost his young daughter.
Mr McCann said: “As a family we’d worked with Simon Ermitage before and know what a sensitive, thoughtful writer he is.
“When I read the Peal poem, I could see echoes in it with Madeline’s situation and our loss.”
Pearl: Two Fathers, Two Daughters will air on BBC Radio 4 at 2.30pm on Saturday, September 29.