Luis Suarez got on the scoresheet as Uruguay eased to a 4-0 win over 10-man Ecuador in their Copa America opener on Sunday.
The Barcelona forward found the net just before half time after goals from Nicolas Lodeiro and Edinson Cavani had put the 15-time champions in control of the Group C match-up.
Uruguay eased off in the second half before an own-goal from Ecuador defender Arturo Mina ensured that Oscar Tabarez's side started the tournament with three points.
It took just six minutes for the Uruguayans to open the scoring in Belo Horizonte, with midfielder Lodeiro brilliantly controlling a cross before putting the ball into the far corner of Alexander Dominguez's goal.
Things soon got even worse for Ecuador as Jose Quinteros was shown a red card in the 23rd minute - with help from VAR - after his arm made contact with Lodeiro's head during an aerial challenge.
That sending-off put Uruguay in control and they almost made it two moments later as Cavani forced a good stop from Dominguez and Lodeiro fired over the bar.
The PSG forward also saw an effort tipped onto the post before he doubled Uruguay's tally with an acrobatic volley.
Suarez poked home from close range just before the break to add a third and put game beyond Ecuador's reach.
Despite a quiet second-half, Mina's own-goal 12 minutes from the final whistle gave Uruguay their biggest win in the continental competition since 1967.
It means that Tabarez's side sit comfortably at the top of Group C, with Chile and Japan set to start their campaigns on Monday.
In Sunday's other fixture, Qatar earned a point from their first-ever Copa America game as they came from two goals down to draw 2-2 with Paraguay in Group B.
Qatar, one of the guest teams at the tournament, got off to a difficult start as Oscar Cardozo put Paraguay ahead from the penalty spot within the first five minutes.
Although the guest nation did cause problems, it looked like their first game in the competition would end in defeat as a Derlis Gonzalez doubled Paraguay's lead in the second half with a long-range strike.
However, Qatar did not give up and Almoez Ali was able to pull a goal back in the 68th minute before an own-goal from Juan Rodrigo Rojas completed the comeback nine minutes later.
The result gave both sides a point and leaves Argentina bottom of the Group B table after their 2-0 defeat against Colombia on Saturday.
Qatar face group leaders Colombia in their next game, while Paraguay will play Lionel Scaloni's side.