Mitesh Patel, 37, had been unfaithful to wife Jessica, 34, throughout their marriage before allegedly killing her at the marital home.
The people he cheated on her with included blokes he met for sexual intercourse on the internet, it was said.
The couple married after meeting at university and both worked as pharmacists at a chemist's shop they owned in Middlesbrough, Teesside.
Judge James Goss QC told potential jurors at Teesside crown court that they would be excused from sitting on the trial if they had used Grindr in the last seven years.
The couple married after meeting at university and worked as pharmacists at their shop in Middlesbrough.
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Mrs Patel was found dead in May after a 999 call had been made.
The prosecution is expected to begin its case tomorrow.
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