A notorious convenience store at the "epicentre" of criminality in Beverley Road has closed.
Matters reached a head in April this year when trading standards officers seized 50,000 smuggled and counterfeit cigarettes and tobacco during a search of the property.
Now the shop lease has been terminated by the landlord.
Humberside Police Neighbourhoods Inspector Mark Peasgood said: "This premises has been the epicentre of antisocial behaviour and persistent street drinking for years.
"The issues have been causing constant problems for the local residents.
"People living in the area told us about the problems of drink-related crime, disorder and antisocial behaviour and we are now very happy to report that it has closed its doors.
"We revoked the alcohol licence, and brought prosecutions from both community safety licensing and trading standards for numerous offences. "
Insp Peasgood said the latest seizure proved to be final nail in the shop's coffin.
"The landlords were notified of this criminality. They have now terminated the lease. The shutters are down and the locks have been changed.
"This is the second successful closure order at premises involving crimes such as illicit cigarettes and smuggled and cheap alcohol. The other premises was on Hessle Road.
"Cheap smuggled cigarettes and booze can be bought at pocket money prices and are therefore alluring to vulnerable children. It also causes and contributes to drink-related crime, disorder and antisocial behaviour.
"Once again this shows that by working in partnership with the local authority and trading standards we can collectively make a huge difference.
"The closure of this shop will have a positive impact on our local residents and community.
"It sends a stark warning to those involved in illicit tobacco and supplying cheap smuggled alcohol that we will seek every avenue to disrupt them and, if we can, bring them to justice."
Councillor Mike Ross, who represents the area, said: "This is very good news for long-suffering residents and represents another step in the right direction."
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