THERESA May last night lost control of the Brexit process to Remainer MPs in a humiliating defeat.
Three Tory ministers quit so they could join the rebellion.
MPs voted by 329 to 302 to hijack the parliamentary timetable to hold indicative votes tomorrow on how they want Brexit to proceed.
Hardline leavers fear the votes will engineer a softer Brexit.
MPs could demand Norway-style European Economic Area membership, a customs union or even a second In/Out referendum.
Business Minister Richard Harrington, Health Minister Steve Brine and Foreign Office Minister Alistair Burt all voted for the amendment tabled by Tory grandee Sir Oliver Letwin.
In his letter of resignation, Mr Harrington accused the Government of playing “roulette with the lives and livelihoods” of Brits.
The three were among 30 Tories — including eight former Cabinet ministers — who backed the amendment.
George Eustice, who quit as Environment Minister last month over the PM’s decision to let MPs vote to delay Brexit, was one of four abstainers.
Just eight Labour MPs backed the Government.
Sources said Mrs May has also been told she should expect up to 30 resignations from Remainers if they are not given free votes on the upcoming indicative ballots.
The PM had mounted a desperate last-ditch bid to fend off the revolt by ruling out a No Deal Brexit unless the Commons agreed to it.
She had called on all MPs yesterday to break the deadlock and “confront the reality of the hard choices before us”.
She declared: “Unless this House agrees to it, No Deal will not happen.”
But her words failed to quell the Tory rebellion.
And seething Leaver Crispin Blunt accused Mrs May to her face of “the most shameful surrender by a British leader since Singapore in 1942”.
The PM’s de facto deputy, Cabinet Office minister David Lidington, had tried to pick off wavering Tory rebels by promising the Government would hold its own indicative votes.
But his eleventh-hour plea failed to sway Tory Remainers.
But Mr Lidington managed to talk several out of quitting, including Parliamentary Private Secretary Alex Chalk, who told The Sun: “Given the PM has just given me an undertaking to make time for the indicative votes process by the end of next week, I have changed my mind and will now vote with the Government”.
The Brexit department admitted power over Britain’s departure has now been handed to the backbenches.
MPS VOTE TO TAKE OVER
A spokesman said: “This amendment upends the balance between our democratic institutions and sets a dangerous, unpredictable precedent.
“Any options considered must be deliverable in negotiations with the EU.
“Parliament should take account of how long these would take and if they would require a longer extension.”
The PM separately confirmed to Labour ‘Leaver’ Caroline Flint that Parliament would have more of say in the second phase on Brexit negotiations.
Earlier, Mrs May had been forced to rip up plans for another vote on her exit deal — pencilled in for today — after being unable to muster enough support to get it through.
She had also rejected calls for a “confirmatory” referendum on her deal as the ballot paper would also carry an option to Remain.
'TORY PSYCHO DRAMA'
But the PM said Parliament would have more say in the next set of Brexit negotiations.
As MPs from all sides tore into her over the deadlock, she dodged demands to say if she would resign in the “national interest” to get her deal passed.
She said: “This is about making sure we leave the EU and do it in the way that’s best for this country.”
TiG MP Anna Soubry said the country was crying out for leadership.
Labour’s Jess Philips said Parliament was stuck in a “Tory psycho drama” where every decision appeared to be influenced by whether Boris Johnson would or could become Prime Minister.
Labour’s Stephen Kinnock last night said he believed 113 Tory MPs would back a Norway-style Brexit if the PM’s deal was defeated a third time.