Wales return to action on Saturday when they host England at Parc y Scarlets.
Wayne Pivac's Wales side have recorded just two wins this year, against Italy in February and Georgia last weekend, amassing six consecutive defeats in between.
How will they fare against Eddie Jones' Six Nations title winners?
We asked our rugby writers to make their predictions:
Mark Orders: Wales 12-39 England
There are many things working against Wales for this one, among them the absence of certain key players, England being bang in form, the hosts not playing well themselves and there being no supporters in Llanelli on Saturday because of coronavirus restrictions.
It doesn't bode well.
The first priority for Wayne Pivac's side will be to try to match England in the set-pieces.
A line through Ireland suggests that will be easier said than done. The Irish pillaged the Welsh line-out, eight days before enduring all kinds of problems in that area at Twickenham. Similarly, the Irish scrum hit problems in London after dominating Wales in the pushing and shoving game in Dublin.
Wales have an inexperienced back row going up against an English trio which schooled the All Blacks barely a year ago. To say the challenge for Shane Lewis-Hughes and James Botham is a big one is to deal in serious understatement.
It's hard to see the hosts setting in place a solid platform, while behind, England again have a familiar look compared with their rivals.
The expected damp weather may put a check on the visitors' ambitions, but Wales are going through a difficult spell and it will take a lot for them to be competitive.
Matt Southcombe: Wales 9-34 England
There has been little evidence to suggest that Wales, in their current state, are capable of causing England too many problems.
This is not a Wales v England match as we know it. These occasions, under the roof in Cardiff, are like no other. The air fizzes with energy, the crowd plays a part.
There will be none of that on Saturday at an empty Parc y Scarlets. Wales v England will never have been such a low-key occasion.
Without the external factors, it will simply be a test of which rugby team is the best. England are comfortable favourites.
The two teams are at different stages of their journey. England have continuity of selection and philosophies, Wales have experienced the upheaval of coaches and styles. Not to mention a number of injuries to key players.
Ireland dominated Wales up front out in Dublin. Welsh backs never stood a chance. Last week, England eased past the Irish. It all looks ominous.
England are firing on all cylinders and Wales have stuttered throughout the autumn series.
All signs point to an English victory in Llanelli.
Simon Thomas: Wales 11-33 England
It’s a long time since there has been such a sense of dread and foreboding among the Welsh public ahead of a game against England.
It reminds me of the mood of trepidation back in the mid 1990s and early noughties.
There is good reason to be fearful, given England’s dominant performance against an Irish team which had only just dismantled Wales.
Moreover, Wayne Pivac is without key figures like Josh Navidi, Ken Owens, Justin Tipuric, Liam Williams, Jonathan Davies and Ross Moriarty.
Plus there is no home support to urge on the depleted and fresh-faced Welsh team.
So, logically, everything points to a comfortable England victory. You just hope Pivac’s young charges can provide some hope for the future amid the gloom and avoid losing by a cricket score. There is talent there if the set-piece can just hold up to provide some kind of platform.
Weighing everything up, I go for England to win 33-11.
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Ben James: Wales 12-33 England
Wales are 7/1 to win this match. A home match for Wales.
That’s not a good sign.
England’s attack isn’t firing on all cylinders, but their defence is.
Unlike Ireland, Wales won’t turn down kickable penalties but they need more than that.
They need to stretch England or they’ll get suffocated quite easily.
It could be a long afternoon.