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Massachusetts Institute of Technology (MIT), engineers reveal stages of liver regeneration in hopes of helping individuals with liver disease We have developed a new liver tissue model to help with,, according to a new study published in the Journal of the National Academy of Sciences, Proceedings. According to a media release from MIT, researchers may be able to avoid some liver transplants by finding effective ways to stimulate the liver to regenerate naturally, and the liver donated after the transplant. He said it could help his growth.
Liver specialists say that most patients who require liver transplantation have viral hepatitis, primary biliary cholangitis (PBC), cancer, fatty liver disease, etc. He told Fox News that he is often diagnosed with chronic illness. Researchers hope that by learning how to take advantage of the regenerative properties of the liver, doctors will have more options for treating chronic liver disease.
Massachusetts Institute of Technology Campus View 2020 Technology of Technology in Cambridge, Massachusetts, July 8, 2014. (Maddie Meyer / Getty Images)
According to MIT, even if 70% of the liver is removed, the rest of the tissue is still that tissue. Can be played in full size within a few months. Meredith Stone is a 50-year-old medical professional who was diagnosed with primary biliary cholangitis. It is an autoimmune disease that attacks the bile ducts of the liver and damages the liver. She shared that Stone wasn't part of her study, but she's currently suffering from cirrhosis, even though she hasn't drank alcohol for over 20 years. Stone told Fox News that she is currently takingmedications such as Ocaribaand ursodial in hopes of slowing her disease progression and preventing liver transplants. Told.
"I heard about this study and hoped that these researchers could find a way to help the liver regenerate. It's part of that mind. "There isn't much research on PBC, and they can find ways to help my liver and others dealing with catastrophic liver disease," Stone added. I hope. "
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Researchers understand regeneration A study from mice was used for the pathways that occur after liver damage or disease. According to the report, one of the key factors is the interrelationship between cells in the liver called hepatocytes and cells that line the inside of blood vessels called endothelial cells. Researchers explained that hepatocytes produce factors that help blood vessel development, and endothelial cells produce growth factors that help hepatocytes grow. Researchers also said that previous studies in mice found that blood flow was another factor in promoting liver regeneration.
3D Illustration Anatomy of Human Organs (Liver)(ISTOCK)
MIT researchers wanted to model the regenerative interactions of the liver, so Christopher Chen, MD , Teamed up with PhD. William F. Warren, a prominent professor of biomedical engineering at Boston University, designs microfluidic devices with channels that act like blood vessels.
Researchers grow blood vessels along one of these microfluidic channels and addhepatocyte-derived aggregates from human organ donors.
They developed a chip designed to allow molecules such as growth factors to flow between blood vessels and hepatic spheroids in response to release. This design allowed researchers to knock out genes of a particular cell type and see how they affect the overall regeneration process.
In the release, Sangeeta Bhatia, a member of the Koch Institute for Integrated Cancer and the Institute for Medical Engineering Science at MIT, said: It is involved in the regeneration of the liver in mice, some of which appear to be important to humans, but could not understand all the clues for the proliferation of human liver cells.
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This " The "regeneration on chip" model did not stimulate hepatocytes to initiate division when fluid flow increased. This is part of the cycle involved in liver regeneration. However, they found that hepatocytes entered the mitotic cycle if they also provided an inflammatory signal called the cytokine IL-1-β, Release said.
Researchers also blocked endothelial cell genes involved in the production of prostaglandin E2 (PGE2), a molecule that is also involved in zebrafish liver regeneration. By blocking the genes in these cells, it was reportedly possible to demonstrate that this molecule stimulates human hepatocytes to enter the cell division cycle.
Liver transplantation by a liver transplant surgeon. (AnalÛgico)
The team hasother growth factors and molecules produced on the model during liver regeneration. } I am planning to explore. They also want to find a signal that tells the liver when to stop playing.
"Currently, if a patient suffers from liver failure, he or she does not know if he or she will recover and needs a transplant, but if he knows who is robust. Regenerative reactions, and if we needed to stabilize them for a short time, we were able to escape those patients from transplantation, "Batia said in a MIT announcement.
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Bhatia is a team of researchers Hope to be able to utilize molecules to help treat patients with liver failure. Researchers also said that another possibility could be for doctors to use biomarkers to determine the likelihood that a patient's liver will regenerate spontaneously.
